Bioprexum Plus

Bioprexum Plus Overdosage

perindopril + indapamide

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Servier
Full Prescribing Info
Overdosage
Symptoms: The most likely adverse reaction in cases of overdose is hypotension, sometimes associated with nausea, vomiting, cramps, dizziness, sleepiness, mental confusion, oliguria which may progress to anuria (due to hypovolemia). Salt and water disturbances (low sodium and potassium levels) may occur.
Treatment: The first measures to be taken consist of rapidly eliminating the product(s) ingested by gastric lavage and/or administration of activated charcoal, then restoring fluid and electrolyte balance in a specialized center until they return to normal.
If marked hypotension occurs, this can be treated by placing the patient in a supine position with the head lowered. If necessary an IV infusion of isotonic saline may be given or any other method of volemic expansion may be used.
Perindoprilat, the active form of perindopril, can be dialysed (see Pharmacokinetics under Actions).
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